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regenerative dentistry

THE PRF : PLatelet-RICH FIBRIN
natural autologous blood concentrate

a natural autologous platelet concentrate
angiogenesis booster
for the regeneration and healing of damaged tissue

THE FIBRIN PLATFORM : PRF
THE SECOND REVOLUTION IN REGENERATIVE DENTISTRY

WHAT IS THE PLATELET-RICH FIBRIN or PRF ?

Therapeutics using Platelet-Rich Fibrin or PRF (J. Choukroun, Schleicher 2000) make it possible to manufacture a biological fibrin membrane, entirely autologous because it does not contain any adjuvant, enriched with natural cellular growth factors, to promote angiogenesis and the growth of new tissues during bone and gingival grafts.

Platelet-Rich Plasma or PRP was initially developed to increase the number of blood platelets in scar sites. But the use of anticoagulants in its preparation, of animal origin, does not make this protocol optimal, even if the cure is judged, it, quasi optimal.

Some time after the appearance of Platelet-Rich Plasma In the 2000s, PRF or Platelet-Rich Fibrin was introduced into the medical world by Dr. Schleicher and Dr. Joseph Choukroun, an anesthesiologist in Nice, oriented in pain management. Dr. Choukroun’s starting point for the development of PRF was to imagine a medical therapy that would allow the introduction of a concentrate of blood platelets into wounds to effectively increase the body’s natural healing capacity, thanks to the platelet nail. It eliminated anticoagulants from the PRP protocol and recovered the fibrin potential.

Since then, Dr. Joseph Choukroun has traveled the world, from conference to conference, to teach surgical and medical therapeutics with the PRF, which has evolved the concept of medicine and regenerative dentistry.

Today, a medical and scientific community is organized around Dr. Choukroun. It keeps its concepts alive and evolving, with new applications in both dentistry and medicine.

PRF: THE SECOND GENERATION OF PLATELET CONCENTRATE

The
Platelet-Rich Fibrin or PRF
is a by-product of blood (plasma) enriched, by centrifugation, in blood platelets and various blood cells such as macrophages, leukocytes and some stem cells. PRF or Platelet-Rich Fibrin is therefore a second generation autologous platelet or thrombocyte concentrate with an inducing action on the multiplication and differentiation of fibroblasts and osteoblasts.

Fibroblasts are the cells that make the organic framework of gingival and bone tissue. The osteoblasts, as soon as they stop multiplying, begin to manufacture the mineral framework of the bone.

Regenerative dentistry uses PRP (Platelet-Rich Plasma) and PRF ( Platelet-Rich Fibrin).

The new therapies of regenerative medicine and regenerative dentistry allow doctors and dentists to harvest and produce a sufficient amount of PRF from a few milliliters of blood collected from the patient. The plasma is concentrated using a centrifugation technique in the dental office. Several tubes (1 to 8) can be taken according to the needs. A 10 ml tube yields a FRP membrane of about two to three centimeters.

WHAT ARE THE CLINICAL APPLICATIONS OF PRF IN DENTISTRY?

All oral surgery techniques can be combined with PRF: from bone grafts to dental implants, including gingival grafts.

For pre-implant bone grafts, this includes for example:

  • Bone grafts for volume augmentation in onlays and inlays;
  • Sinus Filling Procedures;
  • Alveolar crestal volume augmentation procedures by apposition;
  • Repair of bone defects created by tooth extractions or post-extraction cysts or alveolar fillings;
  • Repair of an oral-sinus communication (fistulas between the sinuses and the mouth).
prf-bg

WHAT IS THE ROLE OF THE PRF?

PRF is an autologous platelet concentrate that activates the process of blood vessel formation, called angiogenesis, and thus the regeneration and healing of damaged tissue.

Indeed, fibrin plays a fundamental role in healing. The growth factors are trapped in its fibers. The fibrin in FRP releases them over longer periods of time, which optimizes healing over several days.

Then, by modifying centrifugation protocols (speed and duration), PRF evolved into a range of blood products with specific indications, with significant new potential impact in many areas of medicine and dentistry:

  • Through improved manufacturing protocols, the optimized PRF properties have significantly increased wound healing compared to previous versions of platelet concentrates.
  • PRF has made tremendous strides in oral surgery with its new platelet concentrate concepts.
  • He has optimized the regenerative potential in all surgical techniques of oral surgery.
  • He helped popularize regenerative dentistry.

WHY IS THERE SO MUCH INTEREST IN REGENERATIVE DENTISTRY AND PRF?

The PRF allows the body to optimize the normal healing pathways at an accelerated rate by stimulating the scar stem cells present in the injured area.

During the natural healing process, blood plays a central role in tissue regeneration by providing various types of healing blood cells, growth factors, cytokines and clotting factors.

The concept of FRP, like that of PRP, is the acceleration and potentiation by natural autologous agents of the body’s natural healing or regenerative processes. All of this is possible thanks to the injection of supra-physiological doses of platelets containing the molecular factors that induce tissue regeneration.

plaquettes sanguines PRP

WHAT ARE THE DIFFERENCES BETWEEN THE PRP AND THE PRF?

  • FRP, unlike PRP, is a total blood autograft. It is totally natural and autologous without any adjuvant (anticoagulant).
  • The PRP is therefore considered a medicine because it contains an anticoagulant of animal origin. The PRF for the same reason does not have the same constraint of the MA.
  • The blood sample for PRF is, as for PRP, completely autologous and taken from the patient at the time of the procedure. The absence of anticoagulant in PRF implies a short handling time in its injectable variant, whereas the opposite is true for PRP
  • PRP requires double centrifugation while PRF requires only one.
  • The biochemical difference between PRP and PRF is that the fibrin of PRP is a macromolecule with tetra-molecular junctions, rigid and the fibrin of PRF is a molecule with tri-molecular junctions giving it a natural and physiological structure of scar matrix of the injured tissue.
  • As it is an auto-transfusion (autologous plasma graft), FRP has no risk of cross-contamination, unlike PRP where an exogenous adjuvant of animal origin (anticoagulant) is added.
  • Unlike PRP collection techniques, PRF is an autologous platelet concentrate with no added anticoagulant, antiplatelet agent, or other blood by-products. No additional anti-coagulant is used for PRF since fibrin aggregation is sought. It exploits the ability of fibrin to form a reticulated lattice that retains blood platelets and scar cells. Thus, FRP induces, over a longer period of time and in a persistent manner, the multiplication and differentiation of fibroblasts and osteoblasts that participate in the fabrication of new soft tissues (gum) and hard tissues (bone).
THE ANTHOLOGY OF OUR CLINICAL CASES

YOU ARE UNIQUE!

CLINICAL CASES OF TISSUE RESOPTION RESULT THANKS TO REGENERATIVE DENTISTRY AND PRF

INITIAL SITUATION VS. CLINICAL OUTCOME